Metabolism of I131-Labeled Thyroxine—Studies With Isolated, Perfused Rat Liver
نویسندگان
چکیده
منابع مشابه
Imatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملimatinib metabolism and disposition in isolated rat perfused liver
imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...
متن کاملCo-Exposure Effects of LPS with Various Aflatoxin B1 Doses in Isolated Perfused Rat Liver Model
Background: Activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. Aflatoxin B1 (AFB1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. This study was conducted to examine the effect of co-exposure LPS and various aflatoxin B1 doses on the damage hepatic parameters in isolated perfused rat liver. Methods: Thirty-two male wistar rats (250-3...
متن کاملXylitol metabolism in the isolated perfused rat liver.
1. Loading the isolated perfused liver from well-fed rats with xylitol (20mm) caused a depletion of adenine nucleotides and P(i) and an accumulation of alpha-glycerophosphate. The ATP content fell to 66% of the control value after 10min and to 32% after 80min. The ADP and AMP contents also fell. After 80min 63% of the total adenine nucleotides and 59% of the P(i) had been lost. 2. The alpha-gly...
متن کاملPhthalate ester metabolism in the isolated, perfused rat liver system.
A series of experiments, performed at Johns Hopkins University, which led to our finding that plasticizers are extracted from poly-(vinyl chloride) (PVC) plastic by blood and biologic fluids will be described. The experiments began with the appearance of an unknown compound in the isolated perfused liver system. Livers were perfused with a mixture of synthetic plasma containing bovine serum alb...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Legacy Content
سال: 1953
ISSN: 0002-9513
DOI: 10.1152/ajplegacy.1953.172.3.561